keywords:"kovalentně uzavřená kruhová DNA HBV (cccDNA)" - Search Results - Digital Repository

guest :: login Digital Repository
		Search		Submit		Help		About

Home > Search Results: keywords:"kovalentně uzavřená kruhová DNA HBV (cccDNA)"

Search:

Search Tips :: Advanced Search

Search collections:

Sort by:	Display results:	Output format:

	Interaction of hepatitis B virus proteins with mechanisms of innate immunity Vávrová, Petra ; Hirsch, Ivan (advisor) ; Horníková, Lenka (referee) Specific aim of this bibliographic research is to elucidate interaction of hepatitis B virus proteins with mechanisms of the innate immunity. The work will specially analyze the role of viral proteins before and after their transport from the infected cell. Because of the central role of cccDNA for virus persistence in human organism, the work will study the effects of restriction factors on its possible destruction and eradication. The research will be focused on the effect of viral proteins during acute, chronic and occult infection. Detailed record
	Effect of epigenetic modifications on replication and transcription of hepatitis B virus DNA Hofman, Tomáš ; Hirsch, Ivan (advisor) ; Roučová, Kristina (referee) The hepatitis B virus forms in a nuclei of infected hepatocytes a stable cccDNA resistant to degradation and capable to persist for many years. The main role in the persistence of cccDNA play the epigenetic mechanisms that regulates viral transcription and replication in various stages of the infection. Major epigenetic mechanisms involved in the regulation of HBV include CpG islands methylation, cccDNA-bound histone acetylation and methylation and RNA interference. CpG methylation is associated with the activity of capsid protein, which binds to the cccDNA and promotes transcription and structurally distinguishes viral and the host genome. HBx protein besides CpG methylation mainly affects histone modifications via its interaction with host proteins and thus eliminates the inhibitory effects and promotes the active modifications favoring virus transcription. This work summarizes current knowledges concerning the cccDNA epigenetic regulation. Keywords: HBV, cccDNA, replication and transcription of HBV DNA, histone modifications, methylation of CpG, CpG islands, HBx, HBc, IFNα, IL-6 Detailed record
	Effect of restriction factors on replication of hepatitis B virus Kunteová, Kateřina ; Hirsch, Ivan (advisor) ; Sýkora, Michal (referee) Specific aim of this bibliographic research is to elucidate the effects of cellular restriction factors on HBV replication. The work will specially analyze the role of the innate and natural immunity and to compare the effect of analogical or identical restriction factors on HBV and HIV-1 replication. Because of the central role of cccDNA for virus persistence in human organism, the work will study the effects of restriction factors on its possible destruction and eradication and a possible HBV cure. The research will also be focused on the effect of restriction factors during acute, chronic and occult infection. Powered by TCPDF (www.tcpdf.org) Detailed record

Interested in being notified about new results for this query?
Subscribe to the RSS feed.

Digital Repository :: :: :: ::
Powered by v1.1.2
Maintained by

This site is also available in the following languages:
Česky English